CD28
CD28 is a protein that in humans is encoded by the CD28 gene. CD28 is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. It is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins.
Function[edit | edit source]
CD28 is the primary co-stimulatory molecule that has a crucial role in the control of T cell responses. The engagement of CD28 by its ligands CD80 and CD86 provides the second signal required for the full activation of naive T cells following TCR (T cell receptor) stimulation.
Clinical significance[edit | edit source]
CD28 is involved in several diseases including autoimmune diseases and cancer. In autoimmune diseases, the function of CD28 is often dysregulated leading to excessive T cell responses. In cancer, CD28 can be exploited by tumors to evade the immune response.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- CD28 at WikiMD
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Contributors: Prab R. Tumpati, MD
