CD31
CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule), is a type of protein that is encoded by the PECAM1 gene in humans. It is a member of the immunoglobulin superfamily and is primarily found on the surface of endothelial cells and platelets.
Function[edit | edit source]
CD31 plays a crucial role in removing aged neutrophils from the body. It is also involved in the process of leukocyte transmigration, angiogenesis, and integrin activation. It is a key player in the process of cell-cell adhesion, a function that is supported by its localization to areas of cell-cell contact.
Clinical significance[edit | edit source]
CD31 has been used as a endothelial cell marker in histological staining. It is also used in medical research to identify and isolate endothelial cells. In addition, it has been associated with certain types of cancer, including melanoma and breast cancer.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- PECAM1 at the US National Library of Medicine Medical Subject Headings (MeSH)
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Contributors: Prab R. Tumpati, MD
