CD146

CD146 also known as Melanoma Cell Adhesion Molecule (MCAM) or Cell surface glycoprotein MUC18, is a protein that in humans is encoded by the MCAM gene. CD146 plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a cell adhesion molecule, CD146 plays a role in the interaction of activated endothelial cells with leukocytes, monocytes, and lymphocytes.

Structure

The CD146 protein is a member of the immunoglobulin superfamily, with a structure similar to that of the neural cell adhesion molecule. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. It is also thought to play a role in the process of angiogenesis, the formation of new blood vessels from pre-existing vessels.

Function

CD146 is involved in a variety of biological processes. It is involved in the adhesion and migration of cells, and also in the organization of cells into tissues. It is also involved in the process of angiogenesis, the formation of new blood vessels from pre-existing vessels. CD146 is also thought to play a role in the immune response, as it is involved in the interaction of activated endothelial cells with leukocytes, monocytes, and lymphocytes.

Clinical significance

CD146 has been found to be overexpressed in several types of cancer, including melanoma, breast cancer, and prostate cancer. It is thought that the overexpression of CD146 may contribute to the aggressive behavior of these cancers. CD146 is also thought to play a role in the development of cardiovascular disease, as it is involved in the formation of new blood vessels, a process that is often dysregulated in cardiovascular disease.

See also

• Cell adhesion
• Endothelial cells
• Leukocytes
• Monocytes
• Lymphocytes
• Angiogenesis
• Melanoma
• Breast cancer
• Prostate cancer
• Cardiovascular disease