CD36

CD36 (also known as platelet glycoprotein 4, fatty acid translocase (FAT), scavenger receptor class B member 3 (SCARB3)) is a protein that in humans is encoded by the CD36 gene. CD36 is a member of the class B scavenger receptor family of cell surface proteins, which play a major role in metabolism, inflammation, and immune response.

Structure

CD36 is a glycoprotein that is found on the surface of many cell types in vertebrate animals and is also present in some invertebrates. The human CD36 protein is encoded by the CD36 gene located on chromosome 7. The CD36 protein is a member of the class B scavenger receptor family, which includes two transmembrane domains, two cytoplasmic domains, and a short extracellular loop.

Function

CD36 binds many ligands including lipoproteins, collagen, thrombospondin, and long chain fatty acids. It is involved in fat metabolism, immune response, apoptosis, angiogenesis, and the pathogenesis of atherosclerosis. CD36 is also involved in the uptake of oxidized low density lipoprotein (oxLDL), and it is believed to play a significant role in the development of atherosclerosis.

Clinical significance

Mutations in the CD36 gene have been associated with metabolic disorders such as insulin resistance, metabolic syndrome, and coronary heart disease. CD36 deficiency is also associated with a number of diseases, including Stevens-Johnson syndrome and a form of malaria.

See also

• Scavenger receptor
• Metabolic disorder
• Atherosclerosis
• Stevens-Johnson syndrome
• Malaria

External links

• CD36 at the US National Library of Medicine Medical Subject Headings (MeSH)

CD36 Resources
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