CD36

From WikiMD's Food, Medicine & Wellness Encyclopedia

CD36 (also known as platelet glycoprotein 4, fatty acid translocase (FAT), scavenger receptor class B member 3 (SCARB3)) is a protein that in humans is encoded by the CD36 gene. CD36 is a member of the class B scavenger receptor family of cell surface proteins, which play a major role in metabolism, inflammation, and immune response.

Structure[edit | edit source]

CD36 is a glycoprotein that is found on the surface of many cell types in vertebrate animals and is also present in some invertebrates. The human CD36 protein is encoded by the CD36 gene located on chromosome 7. The CD36 protein is a member of the class B scavenger receptor family, which includes two transmembrane domains, two cytoplasmic domains, and a short extracellular loop.

Function[edit | edit source]

CD36 binds many ligands including lipoproteins, collagen, thrombospondin, and long chain fatty acids. It is involved in fat metabolism, immune response, apoptosis, angiogenesis, and the pathogenesis of atherosclerosis. CD36 is also involved in the uptake of oxidized low density lipoprotein (oxLDL), and it is believed to play a significant role in the development of atherosclerosis.

Clinical significance[edit | edit source]

Mutations in the CD36 gene have been associated with metabolic disorders such as insulin resistance, metabolic syndrome, and coronary heart disease. CD36 deficiency is also associated with a number of diseases, including Stevens-Johnson syndrome and a form of malaria.

See also[edit | edit source]

References[edit | edit source]


External links[edit | edit source]

CD36 Resources
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Contributors: Prab R. Tumpati, MD