CD38

CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4, CD8, B cells and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.

Function

CD38 is a multifunctional enzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. This molecule is necessary for the regulation of intracellular calcium.

Clinical significance

CD38 has been used as a prognostic marker in leukemia. It is also a target of the drug Daratumumab, which is used in the treatment of multiple myeloma.

See also

• Cluster of differentiation
• Daratumumab

External links

• CD38 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.