CD53

CD53 is a protein that in humans is encoded by the CD53 gene. CD53 is a member of the tetraspanin family, a group of proteins involved in various cellular processes including cell adhesion and signal transduction.

Function

CD53 is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation.

Clinical significance

Mutations in the CD53 gene have been associated with recurrent infections, suggesting a role in the immune system's response to pathogens. Further research is needed to fully understand the implications of these mutations and their potential role in immune disorders.

Interactions

CD53 has been shown to interact with:

• CD81
• CD82
• CD9

See also

• Cluster of differentiation

External links

• CD53 at GeneCards

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