CD57
CD57, also known as HNK-1 or Leu-7, is a carbohydrate antigen present on various types of immune cells. It is used as a marker for certain types of lymphocytes, and its expression is associated with specific stages of cell differentiation and activation.
Function[edit | edit source]
CD57 is expressed on the surface of natural killer cells, T lymphocytes, and some B lymphocytes. It is involved in cell-cell adhesion, cell migration, and modulating cell signaling. CD57+ cells have been shown to have potent cytotoxic activity and are involved in the immune response to viral infections and cancer.
Clinical significance[edit | edit source]
In the clinical setting, CD57 is used as a marker for certain types of lymphoma and neuroendocrine tumors. It is also used to monitor the immune status of individuals with chronic Lyme disease, as the number of CD57+ cells has been shown to correlate with disease activity.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
