CD57

CD57, also known as HNK-1 or Leu-7, is a carbohydrate antigen present on various types of immune cells. It is used as a marker for certain types of lymphocytes, and its expression is associated with specific stages of cell differentiation and activation.

Function

CD57 is expressed on the surface of natural killer cells, T lymphocytes, and some B lymphocytes. It is involved in cell-cell adhesion, cell migration, and modulating cell signaling. CD57+ cells have been shown to have potent cytotoxic activity and are involved in the immune response to viral infections and cancer.

Clinical significance

In the clinical setting, CD57 is used as a marker for certain types of lymphoma and neuroendocrine tumors. It is also used to monitor the immune status of individuals with chronic Lyme disease, as the number of CD57+ cells has been shown to correlate with disease activity.

See also

• CD markers
• Natural killer cell
• Lymphocyte

References

CD57 Resources
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