CD61
CD61 is a protein that in humans is encoded by the ITGB3 gene. It is also known as integrin beta-3 or glycoprotein IIIa (GPIIIa). This protein is a part of the integrin family and interacts with integrin alpha-IIb to form a complex known as the platelet glycoprotein complex. This complex plays a crucial role in blood coagulation and wound healing.
Function[edit | edit source]
CD61, as a part of the platelet glycoprotein complex, is involved in the process of blood coagulation and wound healing. It helps in the formation of blood clots by facilitating the aggregation of platelets. The protein also plays a role in the process of cell adhesion, which is crucial for the healing of wounds.
Clinical significance[edit | edit source]
Mutations in the ITGB3 gene that encodes CD61 can lead to diseases such as Glanzmann's thrombasthenia, which is characterized by a lack of platelet aggregation and prolonged bleeding times. CD61 is also a target for certain anti-platelet drugs like abciximab, which inhibit the function of the platelet glycoprotein complex and prevent blood clot formation.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- ITGB3 gene on NCBI
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Contributors: Prab R. Tumpati, MD
