CD63

CD63 is a protein that in humans is encoded by the CD63 gene. It is a member of the tetraspanin superfamily, which is characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.

Function

CD63 is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation. It is also present in melanoma cells and is commonly used as a biomarker to detect the presence of these cells in the body.

Clinical significance

CD63 is used in the diagnosis of melanoma, a type of skin cancer. It is also involved in various diseases such as Hermansky-Pudlak syndrome, which is a disorder of lysosomal trafficking.

Interactions

CD63 has been shown to interact with integrins, a large family of cell surface receptors, and plays a role in various cellular processes including cell adhesion and cell signaling.

See also

• Cluster of differentiation
• Tetraspanin
• Melanoma

References

‎ ‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian