CD79a
CD79a is a protein that in humans is encoded by the CD79A gene. It is also known as Ig-alpha (Immunoglobulin-alpha) and is involved in the development and functioning of B cells, a type of white blood cell.
Function[edit | edit source]
CD79a and CD79b proteins are necessary for initiating the signal transduction cascade that is activated by binding of antigen to the B cell antigen receptor (BCR) complex. These proteins also are necessary for B cell development. Defects in the CD79A gene can result in agammaglobulinemia-3.
Clinical significance[edit | edit source]
Mutations in the CD79A gene are associated with agammaglobulinemia-3, a condition that affects the immune system and results in a lack of B cells and immunoglobulins, leading to recurrent bacterial infections.
Interactions[edit | edit source]
CD79a has been shown to interact with CD79B, Lyn, and Syk.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- Human CD79A gene details page in the NCBI/NLM/NIH Gene database
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Contributors: Prab R. Tumpati, MD
