CD82 (gene)

CD82 is a gene that in humans is encoded by the CD82 gene. CD82 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.

Function

The CD82 gene encodes a type III transmembrane protein that is found in the cell membrane of various cell types and in intracellular vesicles. This protein is involved in cell adhesion and cell migration, and also participates in several cellular processes including apoptosis, cell proliferation, and the metastatic spread of cancer cells.

Clinical significance

Alterations in the CD82 gene have been associated with various diseases. For instance, decreased expression of this gene has been linked with prostate cancer, breast cancer, and gastric cancer. In addition, mutations in this gene have been implicated in the development of leukemia and lymphoma.

See also

• Cluster of differentiation
• Tetraspanin
• Cell adhesion
• Cell migration

External links

• CD82 at the US National Library of Medicine Medical Subject Headings (MeSH)