CDC45-related protein

The CDC45 protein, encoded by the gene CDC45L in humans, plays a critical role in the initiation of DNA replication and is an essential component of the pre-replication complex. This protein is involved in the early stages of the S phase of the cell cycle, where it works closely with other proteins to ensure accurate DNA replication, a process vital for cell division and the maintenance of genetic stability.

Function

CDC45 functions as part of the CMG complex (Cdc45-MCM-GINS complex), facilitating the unwinding of DNA helix, which allows for the progression of the replication fork during DNA replication. Its interaction with MCM proteins and GINS complex is crucial for the assembly of the active DNA helase, ensuring the fidelity and efficiency of the replication process.

Clinical Significance

Alterations in the expression or function of CDC45 have been implicated in various cancer types, highlighting its potential as a biomarker for cancer diagnosis or prognosis and as a target for therapeutic interventions. Research continues to explore its precise role in cancer biology and potential in cancer therapy.

Genetic Information

The CDC45L gene is located on the long (q) arm of chromosome 22 at position 11.21. Due to its fundamental role in DNA replication, mutations affecting CDC45 function can lead to cell cycle dysregulation and contribute to the development of genetic disorders and cancer.

CDC45-related protein Resources
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