CENTD2

CENTD2 (Centaurin Delta 2) is a protein that in humans is encoded by the CENTD2 gene. This gene is part of the centaurin family, which is involved in various cellular processes, including signal transduction and membrane trafficking.

Function

The CENTD2 protein is known to play a role in the regulation of phosphoinositide 3-kinase (PI3K) signaling pathways. It is involved in the modulation of cell proliferation, cell differentiation, and cell survival. The protein contains a pleckstrin homology (PH) domain, which allows it to bind to phosphoinositides and interact with other proteins involved in intracellular signaling.

Structure

CENTD2 contains several important domains:

• A pleckstrin homology (PH) domain
• A coiled-coil domain
• A GAP (GTPase-activating protein) domain

These domains facilitate its role in cellular signaling and interaction with other proteins.

Expression

The expression of CENTD2 is observed in various tissues, with higher levels in the brain, heart, and skeletal muscle. Its expression is regulated by multiple factors, including growth factors and cytokines.

Clinical Significance

Mutations or dysregulation of the CENTD2 gene have been implicated in several diseases, including certain types of cancer and neurological disorders. Research is ongoing to better understand its role in these conditions and its potential as a therapeutic target.

Related Proteins

CENTD2 is part of the centaurin family, which includes other proteins such as:

• CENTD1
• CENTD3

These proteins share similar domains and functions, contributing to the regulation of intracellular signaling pathways.

See Also

• Phosphoinositide 3-kinase
• Signal transduction
• Cell proliferation
• Cell differentiation
• Cell survival