Cell survival

From WikiMD's Wellness Encyclopedia

Cell Survival is a biological concept that refers to the ability of a cell to remain alive and functional over time. This process is regulated by a complex network of molecular and cellular mechanisms that ensure the cell's ability to adapt to changes in its environment, resist cell death mechanisms, and repair damage to its DNA and other critical components.

Overview[edit | edit source]

Cell survival is a critical aspect of organismal health and survival. It is a dynamic process that involves the interplay of various biological processes, including cell growth, cell division, cell differentiation, and cell death. These processes are tightly regulated to ensure the proper functioning and survival of the cell.

Mechanisms of Cell Survival[edit | edit source]

The mechanisms that regulate cell survival are complex and multifaceted. They include:

  • Cell cycle regulation: The cell cycle is a series of events that take place in a cell leading to its division and duplication. Proper regulation of the cell cycle is crucial for cell survival.
  • DNA repair mechanisms: Cells have a variety of mechanisms to repair damage to their DNA. These mechanisms are critical for preventing mutations that could lead to cell death or cancer.
  • Apoptosis resistance: Apoptosis, or programmed cell death, is a normal part of cell life. However, cells have mechanisms to resist apoptosis when it is not necessary, which is crucial for their survival.
  • Autophagy: This is a process by which cells recycle their own components to provide the necessary nutrients for survival, especially under conditions of nutrient deprivation.

Role in Disease[edit | edit source]

Abnormalities in cell survival mechanisms can lead to a variety of diseases. For example, excessive cell survival can lead to cancer, while insufficient cell survival can lead to neurodegenerative diseases, cardiovascular diseases, and other conditions.

See Also[edit | edit source]

References[edit | edit source]

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Contributors: Prab R. Tumpati, MD