CEP128

CEP128 is a protein that in humans is encoded by the CEP128 gene. This protein is part of the centrosome, a key cellular structure involved in the process of cell division and in the organization of microtubules in the cytoplasm. The centrosome plays a crucial role in the spatial arrangement of microtubules and is essential for the proper execution of mitosis and meiosis, the processes by which cells divide to form new cells.

Function

The CEP128 protein is involved in the maintenance and integrity of the centrosome and plays a role in the regulation of centrosome duplication. Proper centrosome duplication is critical for cell division, ensuring that each daughter cell inherits a single centrosome, which then organizes its microtubules. Abnormalities in centrosome number and structure can lead to errors in chromosome segregation, which may contribute to cancer and other diseases.

Gene

The CEP128 gene is located on a specific chromosome and consists of multiple exons that are spliced together to produce the final mRNA transcript, which is then translated into the protein. The gene's location and sequence are conserved across many species, indicating its importance in cellular functions.

Clinical Significance

Alterations in the CEP128 gene or its protein product may be implicated in various human diseases, particularly those related to cell division errors, such as certain forms of cancer. Research is ongoing to further understand the role of CEP128 in disease and to explore potential therapeutic targets within the centrosome duplication cycle.

See Also

• Centrosome
• Cell division
• Mitosis
• Meiosis
• Microtubule
• Chromosome segregation