Centrosome

Molly Sheehan Wikipedia 1

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Cytokinesis-electron-micrograph

Centrosome

The centrosome is a critical cellular organelle that plays a key role in cell division, cell cycle regulation, and organization of microtubules in animal cells. It is often referred to as the "microtubule organizing center" (MTOC) of the cell. The centrosome is involved in determining the spatial arrangement of cell components and is crucial for processes such as mitosis, meiosis, and cellular morphology.

Structure

The centrosome is composed of two orthogonally arranged cylindrical structures called centrioles, surrounded by an amorphous mass of protein known as the pericentriolar material (PCM). Each centriole is a barrel-shaped structure made of nine triplets of microtubules. The centrosome duplicates once per cell cycle, ensuring that each daughter cell inherits one centrosome.

Function

The primary function of the centrosome is to nucleate and anchor microtubules. During interphase, the centrosome organizes the microtubule cytoskeleton, which is essential for maintaining cell shape, enabling intracellular transport, and positioning organelles within the cell. As cells enter mitosis, the centrosome plays a pivotal role in the formation of the mitotic spindle, a structure composed of microtubules and associated proteins that segregate chromosomes into the daughter cells.

Centrosome Duplication

Centrosome duplication is a tightly regulated process that occurs in coordination with the cell cycle. It begins in the S phase of the cell cycle and is completed by the end of G2 phase, ensuring that each daughter cell receives one centrosome. Errors in centrosome duplication can lead to abnormal numbers of centrosomes, a condition known as centrosome amplification, which is associated with cancer and other diseases.

Centrosome in Disease

Abnormalities in centrosome number and structure are implicated in various human diseases, most notably cancer. Centrosome amplification can lead to aneuploidy and chromosomal instability, hallmarks of many tumors. Additionally, mutations in genes encoding centrosomal proteins have been linked to microcephaly, ciliopathies, and other developmental disorders.

Research and Clinical Significance

Understanding the centrosome's role in cell division and its involvement in disease has been a significant focus of biomedical research. Insights into centrosome function and regulation offer potential therapeutic targets for cancer and other diseases characterized by cell division errors.