CEP135

CEP135 is a protein that in humans is encoded by the CEP135 gene. This protein is a crucial component of the centrosome, playing a significant role in cell division and the maintenance of cellular structure and organization. The CEP135 gene is located on chromosome 5 in humans and consists of multiple exons that encode a protein essential for the proper function of the centrosomes.

Function[edit | edit source]

The primary function of CEP135 is to contribute to the formation and stability of the centrioles, which are key elements of the centrosome. Centrioles are cylindrical structures that are vital for the process of mitosis and meiosis, aiding in the segregation of chromosomes during cell division. CEP135 interacts with other centrosomal proteins, such as BICD2, to ensure the correct duplication and separation of centrioles, which is critical for the generation of two functional daughter cells after division.

In addition to its role in cell division, CEP135 is also implicated in maintaining the structural integrity of the centrosome and is involved in the process of ciliogenesis, which is the formation of cilia. Cilia are small, hair-like structures that protrude from the cell surface and are involved in various signaling pathways and in the movement of cells and fluids.

Clinical Significance[edit | edit source]

Mutations in the CEP135 gene have been associated with certain genetic disorders and diseases. Abnormalities in the function or expression of CEP135 can lead to defects in cell division, which may result in cancer or developmental disorders. Research is ongoing to further understand the role of CEP135 in human diseases and its potential as a target for therapeutic intervention.