CEP97

CEP97 or Centrosomal protein of 97 kDa is a protein that in humans is encoded by the CEP97 gene. This protein is a member of the centrosomal protein family, playing a crucial role in cell cycle regulation, cell division, and the maintenance of cellular structure integrity. CEP97 is predominantly associated with the centrosome, a key organelle involved in organizing microtubules in animal cells.

Function

CEP97 is implicated in the centrosomal assembly and function, which is vital for the proper formation of the spindle apparatus during mitosis and meiosis, ensuring accurate chromosome segregation. It interacts with other centrosomal proteins, such as CP110, to regulate centrosome maturation and cilium formation. The CEP97-CP110 complex is essential for the recruitment of other proteins to the centrosome and for ciliogenesis inhibition during cell division.

Gene

The CEP97 gene is located on human chromosome 3q29. The gene undergoes transcription to produce a messenger RNA (mRNA) that is translated into the CEP97 protein. Variations in this gene may influence the structure and function of the centrosomes, potentially affecting cell division and stability.

Clinical Significance

Alterations in the expression or function of CEP97 can have significant implications for human health. Given its role in cell cycle regulation, abnormalities in CEP97 expression or mutations in the CEP97 gene may contribute to the development of certain cancers by promoting uncontrolled cell proliferation. Furthermore, since centrosomal proteins like CEP97 are involved in ciliogenesis, defects in these proteins can lead to ciliopathies, a group of disorders arising from dysfunctional cilia.

Research

Research on CEP97 continues to uncover its roles beyond centrosomal functions and ciliogenesis. Studies are exploring its potential involvement in signaling pathways, cellular stress responses, and its interaction with other proteins within the cell. Understanding the full spectrum of CEP97's functions and interactions may provide insights into novel therapeutic targets for diseases associated with centrosomal dysfunction and ciliopathies.