CFU-E
CFU-E or Colony-forming unit-erythroid is a type of stem cell that produces erythrocytes, or red blood cells. These cells are a crucial part of the hematopoietic system, which is responsible for the formation of blood cellular components.
Overview[edit | edit source]
CFU-E cells are derived from hematopoietic stem cells (HSCs), which are multipotent stem cells that give rise to all the blood cell types. The process of erythropoiesis, or red blood cell production, begins with the differentiation of HSCs into progenitor cells known as CFU-E cells.
Function[edit | edit source]
The primary function of CFU-E cells is to produce erythrocytes. This process is regulated by a hormone called erythropoietin (EPO), which is produced primarily by the kidneys. When oxygen levels in the body are low, the kidneys produce more EPO, which stimulates the CFU-E cells to produce more erythrocytes.
Clinical Significance[edit | edit source]
Abnormalities in CFU-E cells can lead to various blood disorders. For example, a decrease in the number of CFU-E cells can lead to anemia, a condition characterized by a lack of healthy red blood cells. Conversely, an increase in the number of CFU-E cells can lead to polycythemia, a condition characterized by an excess of red blood cells.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
