CGB5
CGB5 or Chorionic Gonadotropin Beta 5 is a protein that in humans is encoded by the CGB5 gene. It is a member of the glycoprotein hormone beta chain family and an important gene involved in pregnancy.
Function[edit | edit source]
The CGB5 gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic gonadotropin (CG). CG is a heterodimeric hormone, produced by the syncytiotrophoblast, a component of the placenta, and is composed of an alpha and beta subunit. The alpha subunit is common to all 4 human glycoprotein hormones (CG, thyroid-stimulating hormone, luteinizing hormone, and follicle-stimulating hormone), whereas the beta subunit is unique to CG and dictates receptor binding and biological activity.
Clinical Significance[edit | edit source]
CGB5 is essential for the maintenance of pregnancy and differentiation of the placenta. Mutations in the CGB5 gene have been associated with recurrent miscarriage, preeclampsia, and intrauterine growth restriction.
Structure[edit | edit source]
The CGB5 gene is located on the q arm of chromosome 19 at position 13.32 and it spans 6,149 base pairs. The CGB5 gene produces a 22.2 kDa protein composed of 165 amino acids.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD