CHI3L1

CHI3L1 or Chitinase-3-like protein 1 is a protein that in humans is encoded by the CHI3L1 gene. This protein is also known as YKL-40 in the scientific community and is a member of the 18 glycosyl hydrolase family. CHI3L1 is a secreted glycoprotein expressed in various cell types, including macrophages, neutrophils, and vascular endothelial cells.

Function

CHI3L1 is involved in the process of inflammation and tissue remodeling. It is secreted by activated macrophages, chondrocytes, and synovial cells. The protein has been associated with various diseases, including rheumatoid arthritis, cancer, and chronic obstructive pulmonary disease (COPD). It is believed to play a role in cell proliferation and differentiation, as well as in the stimulation of the synthesis of extracellular matrix and collagen.

Clinical significance

Elevated levels of CHI3L1 have been found in the serum and cerebrospinal fluid of patients with various diseases, such as rheumatoid arthritis, asthma, pulmonary fibrosis, and certain types of cancer. This has led to the suggestion that CHI3L1 could be used as a biomarker for these conditions. However, further research is needed to confirm this.

Research

Research into CHI3L1 is ongoing, with studies investigating its role in various diseases and its potential as a therapeutic target. For example, a study published in the Journal of Clinical Investigation found that CHI3L1 is a critical regulator of inflammation and tissue remodeling in COPD.

See also

• Chitinase
• Glycosyl hydrolase
• Biomarker