CKB (gene)

CKB (Creatine Kinase, Brain) is a gene that encodes the B-type creatine kinase protein in humans. This protein is a member of the creatine kinase family and plays a crucial role in energy metabolism in cells.

Function

The CKB gene provides instructions for making a protein called brain-type creatine kinase. This protein is found throughout the body, but it is most abundant in the brain and other parts of the nervous system. The brain-type creatine kinase protein is involved in maintaining the supply of ATP (adenosine triphosphate), which is the main source of energy for cells. It does this by catalyzing the reversible transfer of a phosphate group from creatine phosphate to ADP (adenosine diphosphate) to generate ATP.

Clinical Significance

Mutations in the CKB gene have been associated with certain medical conditions. For example, reduced activity of the brain-type creatine kinase protein has been observed in the brains of individuals with Alzheimer's disease. However, it is unclear how these changes are related to the development of this disease.

See Also

• Creatine kinase
• ATP
• Alzheimer's disease

References

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.