CLDN10

Ideogram_human_chromosome_13

CLDN10

Placeholder image for CLDN10

CLDN10 is a gene that encodes a member of the claudin family of integral membrane proteins. Claudins are essential components of tight junction strands, which are crucial for the formation of tight junctions in epithelial and endothelial cells. The protein encoded by CLDN10 is specifically involved in the regulation of paracellular permeability and ion transport in the kidney.

Function

CLDN10 plays a key role in maintaining the barrier function of the kidney by regulating the movement of ions and solutes across the renal tubular epithelium. It is primarily expressed in the thin ascending limb of Henle's loop and the distal convoluted tubule, where it contributes to the selective permeability of these segments.

Clinical Significance

Mutations in the CLDN10 gene have been associated with various renal disorders, including hypomagnesemia and hypercalciuria. These conditions are characterized by abnormal ion transport in the kidney, leading to electrolyte imbalances and impaired renal function.

Interactions

CLDN10 interacts with other claudin family members and tight junction-associated proteins to form functional tight junction complexes. These interactions are essential for the proper assembly and maintenance of tight junctions in renal epithelial cells.