CLEC10A

CLEC10A (C-type lectin domain family 10 member A), also known as CD301 or MGL1/2, is a protein that in humans is encoded by the CLEC10A gene. This protein is a member of the C-type lectin family, a type of carbohydrate-binding protein.

Function

CLEC10A is a type II transmembrane glycoprotein that is expressed on the surface of dendritic cells. It is involved in the recognition and internalization of glycosylated self- and non-self antigens, and plays a crucial role in the immune response and homeostasis. CLEC10A recognizes and binds high mannose structures on pathogens and antigens, leading to their internalization and processing for antigen presentation.

Clinical significance

Alterations in the expression of CLEC10A have been associated with various diseases. For example, increased expression of CLEC10A has been observed in melanoma cells, suggesting a potential role in tumor progression. Furthermore, CLEC10A has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus.

Research

Research is ongoing to further understand the role of CLEC10A in the immune system and its potential as a therapeutic target in various diseases. For example, targeting CLEC10A with specific antibodies could potentially enhance the immune response against tumors or pathogens.

See also

• C-type lectin
• Dendritic cell
• Glycoprotein
• Autoimmune disease