CLIC5

CLIC5 is a protein that in humans is encoded by the CLIC5 gene. It is a member of the chloride intracellular channel (CLIC) family of proteins. The CLIC family includes chloride channel proteins that function in the formation of ion channels across the plasma membrane, contributing to the regulation of cellular processes such as cell volume, membrane potential, and acidification of intracellular compartments.

Function

The CLIC5 protein is thought to function in the formation of ion channels in the plasma membrane, contributing to the regulation of cellular processes such as cell volume, membrane potential, and acidification of intracellular compartments. It is also involved in the stabilization of the actin cytoskeleton, which plays a crucial role in cell shape, movement, and division.

Clinical significance

Mutations in the CLIC5 gene have been associated with a form of sensorineural hearing loss and renal disease. This suggests that the protein may play a crucial role in the function of sensory cells and kidney cells.

Structure

The CLIC5 protein has a unique structure that allows it to switch between a soluble state and a membrane-bound state. This structural flexibility is thought to be crucial for its function as an ion channel.

See also

• Chloride channel
• Ion channel
• Actin cytoskeleton

References

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