CLIC6

CLIC6 (Chloride Intracellular Channel 6) is a protein that in humans is encoded by the CLIC6 gene. This protein is part of the chloride intracellular channel (CLIC) family of proteins. The CLIC family members are known to function as both chloride channels and enzymes.

Function

The CLIC6 protein is a member of the CLIC family, which includes proteins that function as intracellular chloride channels. These channels are involved in maintaining the correct ionic balance within cells, which is crucial for a variety of cellular processes, including cell volume regulation, pH regulation, and cell migration.

Structure

The CLIC6 protein is composed of 253 amino acids and has a molecular weight of approximately 28 kDa. It has a single transmembrane domain, which allows it to insert into lipid bilayers and form a functional chloride channel.

Clinical Significance

While the exact role of CLIC6 in human health and disease is not fully understood, it has been implicated in a number of conditions. For example, mutations in the CLIC6 gene have been associated with Parkinson's disease, a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra.

See Also

• Chloride channel
• Gene
• Protein
• Parkinson's disease