CNOT9

CNOT9 is a protein that in humans is encoded by the CNOT9 gene. It is a component of the CCR4-NOT complex, which is a global regulator of gene expression, mRNA degradation and RNA polymerase II-mediated transcription.

Function

CNOT9 is a part of the CCR4-NOT complex, which is one of the major cellular machinery involved in the control of gene expression. This complex, which is composed of nine core components, is involved in numerous cellular processes including mRNA degradation, transcription and translation. CNOT9, also known as RQCD1, is one of the core components of this complex and plays a crucial role in its function.

Structure

The CNOT9 protein is composed of 487 amino acids and has a molecular weight of approximately 54 kDa. It contains a RING finger domain, which is a common feature in proteins involved in the regulation of gene expression.

Clinical Significance

Mutations in the CNOT9 gene have been associated with various diseases. For example, a study found that a mutation in this gene was associated with endometriosis, a painful disorder in which tissue that normally lines the inside of the uterus grows outside the uterus.

Research

Research on CNOT9 is ongoing, with studies investigating its role in various biological processes and diseases. For example, a recent study found that CNOT9 is involved in the regulation of cell proliferation and apoptosis, which are crucial processes in cancer development.

File:CNOT9 protein structure.jpg

Structure of the CNOT9 protein.

See Also

• CCR4-NOT
• Endometriosis
• Cell proliferation
• Apoptosis

References

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