COPG2

Ideogram human chromosome 7

COPG2

COPG2, also known as Coatomer protein complex subunit gamma 2, is a protein-coding gene that plays a crucial role in intracellular protein trafficking. It is a subunit of the coatomer protein complex, which is involved in the formation of vesicles that transport proteins between the Golgi apparatus and the endoplasmic reticulum.

Function

COPG2 is essential for maintaining the structural integrity of the coatomer complex and facilitating the budding of vesicles from the Golgi apparatus. These vesicles transport newly synthesized proteins to their appropriate destinations within the cell. Additionally, COPG2 is involved in regulating the retrograde transport of proteins from the Golgi apparatus back to the endoplasmic reticulum.

Clinical Significance

Mutations in the COPG2 gene have been associated with certain genetic disorders that affect protein trafficking and secretion. These disorders can lead to abnormalities in cell function and contribute to the development of various diseases.

Interactions

COPG2 interacts with other subunits of the coatomer complex, as well as with proteins involved in vesicle formation and intracellular transport. These interactions are essential for the proper functioning of the coatomer complex and the efficient transport of proteins within the cell.