COX10
COX10 also known as Cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 is a protein that in humans is encoded by the COX10 gene. It is involved in the final stages of the mitochondrial electron transport chain, specifically in the synthesis of heme A, a component of cytochrome c oxidase (COX).
Function[edit | edit source]
COX10 is a mitochondrial protein involved in the biosynthesis of heme A, a prosthetic group of cytochrome c oxidase (COX). COX is the terminal enzyme of the mitochondrial respiratory chain and is responsible for the transfer of electrons from cytochrome c to oxygen. COX10 catalyzes the conversion of protoheme IX (heme B) to heme O, the penultimate step in the biosynthesis of heme A.
Clinical significance[edit | edit source]
Mutations in the COX10 gene have been associated with mitochondrial complex IV deficiency, a disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs.
Structure[edit | edit source]
The COX10 protein is a member of the heme A:farnesyltransferase family. It is a multi-pass membrane protein that is located in the inner mitochondrial membrane. The protein is predicted to have 8 transmembrane domains.
See also[edit | edit source]
References[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD