CTAG1B

PDB 2bnq EBI

CTAG1B

CTAG1B is a gene that encodes a cancer/testis antigen. It is located on chromosome Xq28 and is a member of the CT (cancer/testis) antigen family. CTAG1B is known to be expressed in a variety of cancers, particularly in testicular cancer and melanoma.

Function

CTAG1B belongs to the cancer/testis antigen family, which are genes that are normally expressed in testis but are also found in various types of cancer. The exact function of CTAG1B is not fully understood, but it is believed to play a role in tumorigenesis and cancer progression.

Clinical Significance

CTAG1B expression has been linked to poor prognosis in certain types of cancer. Studies have shown that high levels of CTAG1B expression are associated with advanced disease stages and lower survival rates in cancer patients. As a result, CTAG1B is being investigated as a potential target for cancer therapy.

Role in Immunotherapy

CTAG1B has gained interest in the field of cancer immunotherapy. Due to its restricted expression in normal tissues and high expression in cancer cells, CTAG1B is considered a promising target for immunotherapeutic approaches, such as cancer vaccines and adoptive T cell therapy.