Cto
Cto - the orotate salt form of carboxyamidotriazole (cai), an orally bioavailable small molecule with potential antiangiogenic and antiproliferative activities. Carboxyamidotriazole binds to and inhibits non voltage operated calcium channels, blocking both ca2+ influx into cells and ca2+ release from intracellular stores, resulting in the disruption of calcium channel mediated signal transduction. Cai inhibits pi3 activity and vascular endothelial growth factor (vegf) signaling. This may inhibit endothelial proliferation, tumor cell growth, invasion and metastasis.
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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Cto for any updates.
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