CUMYL-3TMS-PRINACA

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CUMYL-3TMS-PRINACA is a synthetic cannabinoid that has been used as a designer drug. It is a potent agonist of the cannabinoid receptors, which are part of the endocannabinoid system in the human body. This compound is structurally related to other synthetic cannabinoids such as AB-FUBINACA and 5F-ADB.

Chemical Structure and Properties

CUMYL-3TMS-PRINACA is characterized by its indazole-based structure, which is common among synthetic cannabinoids. The compound includes a 5-fluoropentyl chain and a cumyl group, which contribute to its high affinity for cannabinoid receptors. The presence of the fluorine atom in the pentyl chain is a modification that enhances its potency and metabolic stability.

Pharmacology

CUMYL-3TMS-PRINACA acts as a full agonist at the CB1 and CB2 receptors, which are the primary targets of cannabinoids in the body. Activation of these receptors leads to a range of effects, including psychoactive effects similar to those of tetrahydrocannabinol (THC), the active component of cannabis.

Effects and Toxicity

The effects of CUMYL-3TMS-PRINACA can include euphoria, relaxation, altered perception, and increased appetite. However, due to its high potency, it can also cause severe adverse effects such as anxiety, paranoia, tachycardia, and in some cases, acute toxicity leading to hospitalization. The long-term effects of using synthetic cannabinoids like CUMYL-3TMS-PRINACA are not well understood, but they may include addiction and cognitive impairment.

Legal Status

The legal status of CUMYL-3TMS-PRINACA varies by country. In some jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. In others, it may be legal or unregulated, often sold as "herbal incense" or "research chemicals."

Synthesis and Detection

The synthesis of CUMYL-3TMS-PRINACA involves the reaction of indazole with a carboxylic acid derivative, followed by the introduction of the fluoropentyl chain. Detection of this compound in biological samples can be challenging due to its structural similarity to other synthetic cannabinoids. Advanced analytical techniques such as mass spectrometry and gas chromatography are often used for its identification.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• Designer drugs