CUMYL-3TMS-PRINACA

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Synthetic cannabinoid


CUMYL-3TMS-PRINACA
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
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Legal status
CAS Number 1400742-16-6
PubChem 119025276
DrugBank
ChemSpider 52085456
KEGG


CUMYL-3TMS-PRINACA is a synthetic cannabinoid that has been used in scientific research and is known for its potent activity at the cannabinoid receptors. It is a member of the indazole-3-carboxamide family of synthetic cannabinoids, which are often used as active ingredients in designer drugs.

Chemical Structure[edit | edit source]

Chemical structure of CUMYL-3TMS-PRINACA

CUMYL-3TMS-PRINACA is chemically classified as an indazole-3-carboxamide. Its IUPAC name is 1-(4-cyanobutyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide. The compound features a cyanobutyl group attached to the indazole core, which is a common structural motif in many synthetic cannabinoids.

Pharmacology[edit | edit source]

CUMYL-3TMS-PRINACA acts as a potent agonist at the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including mood, appetite, and pain sensation. The high affinity of CUMYL-3TMS-PRINACA for these receptors contributes to its psychoactive effects.

Legal Status[edit | edit source]

The legal status of CUMYL-3TMS-PRINACA varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. It is often included in legislation targeting synthetic cannabinoids and other novel psychoactive substances.

Health Effects[edit | edit source]

The use of CUMYL-3TMS-PRINACA, like other synthetic cannabinoids, can lead to a range of adverse health effects. These may include tachycardia, hypertension, nausea, vomiting, anxiety, and hallucinations. Severe cases can result in seizures, renal failure, and death.

Synthesis[edit | edit source]

The synthesis of CUMYL-3TMS-PRINACA involves the reaction of an indazole-3-carboxylic acid derivative with a suitable amine. The process typically requires careful control of reaction conditions to ensure the desired product is obtained with high purity.

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Contributors: Prab R. Tumpati, MD