CUMYL-CBMINACA

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Overview[edit | edit source]

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Chemical structure of CUMYL-CBMINACA

CUMYL-CBMINACA is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It is part of a class of compounds that are often used in the manufacture of designer drugs. These substances are frequently found in products marketed as "spice" or "synthetic marijuana".

Chemical Properties[edit | edit source]

CUMYL-CBMINACA is chemically classified as an indazole-based synthetic cannabinoid. Its full chemical name is N-(1-(cyclobutylmethyl)-1''H''-indazole-3-carbonyl)amino-3-methylbutanamide. The compound is known for its high affinity for the CB1 and CB2 receptors, which are part of the endocannabinoid system.

Pharmacology[edit | edit source]

CUMYL-CBMINACA functions as a full agonist at the cannabinoid receptors, mimicking the effects of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. The activation of these receptors by CUMYL-CBMINACA can lead to a range of effects, including euphoria, anxiety, and hallucinations.

Legal Status[edit | edit source]

Due to its potential for abuse and lack of medical use, CUMYL-CBMINACA is classified as a controlled substance in many jurisdictions. It is often included in legislation targeting synthetic cannabinoids and other new psychoactive substances (NPS).

Health Effects[edit | edit source]

The use of CUMYL-CBMINACA has been associated with adverse health effects, including tachycardia, hypertension, nausea, and vomiting. In severe cases, it can lead to seizures, psychosis, and even death. The variability in potency and the presence of unknown adulterants in products containing synthetic cannabinoids increase the risk of harmful effects.

Detection[edit | edit source]

CUMYL-CBMINACA can be detected in biological samples using advanced analytical techniques such as mass spectrometry and gas chromatography. These methods are essential for forensic investigations and for monitoring the presence of synthetic cannabinoids in the population.

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Contributors: Prab R. Tumpati, MD