Mass spectrometry

Mass spectrometry (MS) is an analytical technique that measures the mass-to-charge ratio of ions. The results are typically presented as a mass spectrum, a plot of intensity as a function of the mass-to-charge ratio. Mass spectrometry is used in many different fields and is applied to pure samples as well as complex mixtures.

History[edit | edit source]

The development of mass spectrometry started in the late 19th century with the discovery of Cathode rays by J.J. Thomson. This led to the development of the Mass spectrometer, which separates ions based on their mass-to-charge ratio.

Principles and methods[edit | edit source]

Mass spectrometry works by ionizing chemical compounds to generate charged molecules or molecule fragments and measuring their mass-to-charge ratios. The three essential functions of a mass spectrometer, and the associated spectrometer methods, are:

Ion source
Mass analyzer
Detector

Applications[edit | edit source]

Mass spectrometry has both qualitative and quantitative uses. These include identifying unknown compounds, determining the isotopic composition of elements in a molecule, and determining the structure of a compound by observing its fragmentation. Other uses include quantifying the amount of a compound in a sample or studying the fundamentals of gas phase ion chemistry (the kinetics and energetics of reactions).

References[edit | edit source]

External links[edit | edit source]

American Society for Mass Spectrometry

Mass spectrometry Resources
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