CYP4B1

Cytochrome P450 Family 4 Subfamily B Member 1 (CYP4B1)

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CYP4B1 gene knockout mouse model

Cytochrome P450 Family 4 Subfamily B Member 1 (CYP4B1) is a member of the cytochrome P450 superfamily of enzymes. These enzymes are involved in the metabolism of various substrates in the body, including drugs and endogenous compounds. CYP4B1 is known for its role in the metabolism of fatty acids and the bioactivation of certain procarcinogens.

Structure and Function

CYP4B1 is a heme-containing enzyme that is primarily expressed in the lung, kidney, and liver. It is involved in the oxidation of fatty acids, which is a crucial step in the metabolism of these molecules. The enzyme catalyzes the hydroxylation of the terminal carbon of fatty acids, a process that is important for the regulation of lipid metabolism.

Genetic Variability

The CYP4B1 gene is located on chromosome 1 in humans. Genetic polymorphisms in CYP4B1 can lead to variations in enzyme activity, which may affect an individual's ability to metabolize certain drugs and environmental chemicals. These polymorphisms can have implications for drug efficacy and toxicity.

Clinical Significance

CYP4B1 has been implicated in the bioactivation of certain procarcinogens, such as aromatic amines, which are found in tobacco smoke and certain cooked meats. The enzyme's activity in this context can contribute to the formation of DNA adducts and the initiation of carcinogenesis. Understanding the role of CYP4B1 in these processes is important for assessing cancer risk and developing preventive strategies.

Research and Experimental Models

Research on CYP4B1 often involves the use of knockout mouse models, such as the Cyp4b1^{tm1a(KOMP)Wtsi} model, to study the enzyme's function and its role in disease. These models help elucidate the physiological and pathological roles of CYP4B1 in vivo.

Related Pages

• Cytochrome P450
• Fatty acid metabolism
• Carcinogenesis
• Genetic polymorphism