Calcium dobesilate

dobesilate

Calcium Dobesilate is a vasoprotective medication used primarily in the treatment of chronic venous insufficiency, diabetic retinopathy, and to alleviate the symptoms of hemorrhoids. It is a synthetic compound that belongs to the class of bioflavonoids, substances known for their beneficial effects on blood vessel health and circulation.

Mechanism of Action

Calcium Dobesilate works by reducing blood viscosity and improving the microcirculation and capillary flow. It achieves this through several mechanisms: it decreases the permeability of capillaries, inhibits platelet aggregation, and has antioxidant properties that protect endothelial cells from oxidative stress. These actions help to reduce edema (swelling) and improve blood flow, which are crucial in the management of venous disorders and complications of diabetes affecting the eyes and kidneys.

Indications

The primary indications for Calcium Dobesilate include:

• Chronic venous insufficiency (CVI), a condition characterized by poor blood flow in the veins, leading to symptoms such as swelling, pain, and skin changes.
• Diabetic retinopathy, a diabetes complication that affects the eyes, causing damage to the blood vessels of the light-sensitive tissue at the back of the eye (retina).
• Hemorrhoids, where it is used to alleviate symptoms such as swelling and bleeding.

Dosage and Administration

Calcium Dobesilate is available in capsule and cream form, allowing for both oral and topical administration. The dosage and duration of treatment depend on the severity of the condition being treated and the patient's response to therapy. It is important for patients to follow their healthcare provider's instructions regarding dosage and duration of treatment.

Side Effects

While Calcium Dobesilate is generally well-tolerated, some patients may experience side effects, including gastrointestinal disturbances, skin reactions, or headaches. Severe side effects are rare but can include agranulocytosis, a serious drop in white blood cell count. Patients should seek immediate medical attention if they experience symptoms of severe side effects.

Contraindications

Calcium Dobesilate should not be used in patients with known hypersensitivity to the drug. It is also contraindicated in patients with severe renal (kidney) or hepatic (liver) impairment due to the lack of extensive research in these populations.

Pharmacokinetics

The pharmacokinetic properties of Calcium Dobesilate include its absorption, distribution, metabolism, and excretion processes, which determine the drug's onset of action, duration of effect, and elimination from the body. However, detailed pharmacokinetic data may vary and should be consulted in specific medical literature.

Conclusion

Calcium Dobesilate is a valuable medication in the management of conditions related to venous insufficiency and diabetic complications. Its ability to improve microcirculation and protect vascular structures makes it a useful adjunct in the treatment of CVI, diabetic retinopathy, and hemorrhoids. As with any medication, it is essential for patients to use Calcium Dobesilate under the guidance of a healthcare professional to ensure its safe and effective use.