Calgranulin

Calgranulin is a type of protein that is encoded by the S100A9 gene in humans. It is also known as migration inhibitory factor-related protein 14 (MRP-14) or S100 calcium-binding protein A9 (S100A9). Calgranulin is a member of the S100 protein family, which contains two EF-hand calcium-binding motifs.

Function

Calgranulin is involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. It functions both intracellularly and extracellularly, where it binds to RAGE receptor. This protein is produced by granulocytes and monocytes and is released into the extracellular space during cell activation.

Clinical significance

Calgranulin has been associated with several diseases, including inflammation, cancer, and neurodegenerative diseases. It is also a potential biomarker for certain conditions, such as rheumatoid arthritis and cystic fibrosis.

See also

• S100 protein
• RAGE (receptor)
• Inflammation
• Cancer
• Neurodegenerative disease

External links

• NCBI Gene
• UniProt

Calgranulin Resources
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