Carbohydrate (chondroitin 4) sulfotransferase 13

Carbohydrate (chondroitin 4) sulfotransferase 13 (CHST13), also known as chondroitin 4-O-sulfotransferase 13, is an enzyme that in humans is encoded by the CHST13 gene. This enzyme is part of the glycosaminoglycan biosynthetic pathway and plays a crucial role in the modification of chondroitin sulfate.

Function

CHST13 is a type II transmembrane protein and is a member of the galactose-3-O-sulfotransferase protein family. This family is responsible for the sulfation of proteoglycans in the body. The enzyme specifically transfers sulfate groups to the 4 position of the N-acetylgalactosamine residue of chondroitin. Chondroitin sulfate is a key component of cartilage and contributes to its resilience.

Clinical significance

Alterations in the function of CHST13 have been associated with several diseases. For example, mutations in the CHST13 gene have been linked to Ehlers-Danlos syndrome, a group of disorders that affect the connective tissues supporting the skin, bones, blood vessels, and many other organs and tissues.

See also

• Sulfotransferase
• Chondroitin sulfate
• Ehlers-Danlos syndrome

External links

• CHST13 at the National Center for Biotechnology Information

This article incorporates text from the United States National Library of Medicine, which is in the public domain.