Carol J. Thiele

American cancer researcher

Carol J. Thiele

Carol J. Thiele is a prominent American cancer researcher known for her significant contributions to the study of neuroblastoma, a type of cancer that most often affects children. She is a senior investigator at the National Cancer Institute (NCI), where she leads the Cell and Molecular Biology Section in the Pediatric Oncology Branch.

Early life and education

Carol J. Thiele was born and raised in the United States. She pursued her undergraduate studies in biology, which laid the foundation for her future career in cancer research. Thiele went on to earn her Ph.D. in biochemistry from a prestigious university, where she focused her research on cellular mechanisms and cancer biology.

Career

Thiele joined the National Cancer Institute, a part of the National Institutes of Health (NIH), where she has spent the majority of her career. Her work at the NCI has been pivotal in advancing the understanding of neuroblastoma, a cancer that arises from immature nerve cells and primarily affects infants and young children.

Research contributions

Thiele's research has focused on the molecular and cellular biology of neuroblastoma. She has been instrumental in identifying key genetic and epigenetic factors that contribute to the development and progression of this disease. Her work has led to the discovery of novel therapeutic targets and the development of new treatment strategies aimed at improving outcomes for patients with neuroblastoma.

Dr. Thiele in her laboratory

One of Thiele's significant contributions is her research on the role of MYCN amplification in neuroblastoma. Her studies have helped elucidate how MYCN drives tumor growth and how targeting this oncogene can lead to potential therapeutic interventions. Additionally, Thiele has explored the tumor microenvironment and its impact on neuroblastoma progression, providing insights into how the interaction between cancer cells and their surrounding environment can influence disease outcomes.

Awards and honors

Throughout her career, Carol J. Thiele has received numerous awards and honors in recognition of her contributions to cancer research. Her work has been published in leading scientific journals, and she is frequently invited to speak at international conferences on pediatric oncology and cancer biology.

Related pages

• Neuroblastoma
• National Cancer Institute
• Pediatric oncology
• Cancer research