Caroli
Caroli disease is a rare congenital disorder characterized by the dilation of the bile ducts and is associated with liver disease. It was first described by the French physician Jacques Caroli in 1958. The disease is classified into two types: simple Caroli disease and complex Caroli disease.
Symptoms[edit | edit source]
The symptoms of Caroli disease can vary greatly from person to person. Some people may have no symptoms at all, while others may experience severe abdominal pain, jaundice, and recurrent infections. In severe cases, the disease can lead to liver failure.
Causes[edit | edit source]
Caroli disease is a congenital condition, meaning it is present from birth. It is thought to be caused by a defect in the ductal plate, a structure that forms in the early stages of liver development. This defect leads to the abnormal dilation of the bile ducts.
Diagnosis[edit | edit source]
Diagnosis of Caroli disease is typically made through imaging studies such as ultrasound, computed tomography (CT) scan, or magnetic resonance imaging (MRI). These tests can show the characteristic dilation of the bile ducts. In some cases, a liver biopsy may be needed to confirm the diagnosis.
Treatment[edit | edit source]
There is no cure for Caroli disease, but treatment can help manage the symptoms and prevent complications. This may include antibiotics to treat infections, medications to help control pain, and in severe cases, liver transplantation.
Prognosis[edit | edit source]
The prognosis for Caroli disease can vary greatly depending on the severity of the disease and the presence of other health conditions. With proper management, many people with Caroli disease can live a normal life.
See also[edit | edit source]
| Caroli Resources | |
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References[edit | edit source]
External links[edit | edit source]
Further reading[edit | edit source]
- "Caroli's disease: radiologic spectrum with pathologic correlation." American Journal of Roentgenology. 1995;165(2):309-14.
- "Caroli's disease and Caroli's syndrome." Journal of Hepato-Biliary-Pancreatic Surgery. 2008;15(1):31-5.
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Contributors: Prab R. Tumpati, MD
