Cartazolate
Cartazolate is a pharmacological compound that belongs to the class of pyrazolopyridine derivatives. It acts primarily as an anxiolytic agent and has been studied for its potential in the treatment of anxiety disorders. Cartazolate functions by modulating the activity of the GABAergic system, specifically targeting the GABAA receptor, which plays a crucial role in mediating the inhibitory effects of GABA in the central nervous system (CNS). By enhancing the action of GABA, cartazolate helps in reducing anxiety levels and has been considered for its therapeutic benefits in managing conditions characterized by excessive anxiety and stress.
Pharmacodynamics[edit | edit source]
Cartazolate exhibits its anxiolytic effects through its action on the GABAA receptor, a ligand-gated ion channel that is responsible for mediating the majority of fast synaptic inhibition in the brain. The modulation of this receptor by cartazolate enhances the inhibitory effects of GABA, leading to a reduction in neuronal excitability and an overall calming effect on the CNS. This mechanism is similar to that of other anxiolytic agents, such as benzodiazepines, although the exact binding site and affinity of cartazolate for the GABAA receptor may differ.
Clinical Applications[edit | edit source]
While cartazolate has shown promise in preclinical studies for its anxiolytic properties, its development and clinical use have been limited. The research on cartazolate has contributed to a better understanding of the GABAergic system and its role in anxiety disorders, but as of the last update, cartazolate has not been widely adopted in clinical practice for the treatment of anxiety or other conditions. Its potential side effects, pharmacokinetic profile, and comparative efficacy with other anxiolytics remain areas of ongoing research.
See Also[edit | edit source]
References[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
