Cefaparole

Cefaparole

Cefaparole is a cephalosporin antibiotic used to treat a variety of bacterial infections. It belongs to the class of beta-lactam antibiotics, which work by inhibiting the synthesis of the bacterial cell wall, leading to cell death. Cefaparole is particularly effective against Gram-positive bacteria and some Gram-negative bacteria.

Mechanism of Action

Cefaparole, like other cephalosporins, targets the penicillin-binding proteins (PBPs) located inside the bacterial cell wall. By binding to these proteins, it disrupts the cross-linking of the peptidoglycan layer, which is essential for bacterial cell wall strength and rigidity. This disruption leads to the weakening of the cell wall and eventually causes the bacterial cell to lyse and die.

Pharmacokinetics

Cefaparole is typically administered via intravenous or intramuscular injection. It is well-absorbed and distributed throughout the body, reaching therapeutic concentrations in various tissues and fluids. The drug is primarily excreted unchanged in the urine, making it effective for treating urinary tract infections.

Clinical Uses

Cefaparole is used to treat a range of infections, including:

• Respiratory tract infections
• Skin and soft tissue infections
• Urinary tract infections
• Bone and joint infections
• Intra-abdominal infections

Side Effects

Common side effects of Cefaparole include:

• Nausea
• Diarrhea
• Rash
• Allergic reactions

Serious but rare side effects may include:

• Anaphylaxis
• Clostridioides difficile infection
• Hematologic abnormalities

Contraindications

Cefaparole should not be used in patients with a known allergy to cephalosporins or other beta-lactam antibiotics. Caution is advised in patients with renal impairment.

Related Pages

• Cephalosporin
• Antibiotic
• Beta-lactam antibiotic
• Penicillin-binding protein
• Gram-positive bacteria
• Gram-negative bacteria