Cefbuperazone

Cefbuperazone is a cephalosporin antibiotic, a class of beta-lactam antibiotics that are used in the treatment of various bacterial infections. It is a broad-spectrum antibiotic, meaning it is effective against a wide range of bacteria.

Chemistry

Cefbuperazone belongs to the third generation of cephalosporins. Like all cephalosporins, it contains a beta-lactam ring, a chemical structure that is crucial for its antibacterial activity. The beta-lactam ring interferes with the synthesis of the bacterial cell wall, leading to the death of the bacteria.

Pharmacology

Cefbuperazone works by inhibiting the synthesis of the bacterial cell wall. It binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. This binding leads to the inhibition of the third and last stage of bacterial cell wall synthesis, which is ultimately lethal to the bacteria.

Clinical Use

Cefbuperazone is used to treat a variety of bacterial infections, including those caused by Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae. It is also used in the treatment of infections caused by Pseudomonas aeruginosa, a bacterium that is often resistant to other antibiotics.

Side Effects

Like all antibiotics, cefbuperazone can cause side effects. The most common side effects include nausea, vomiting, and diarrhea. In rare cases, cefbuperazone can cause serious side effects such as allergic reactions, kidney damage, and Clostridium difficile-associated diarrhea.

Resistance

Bacterial resistance to cefbuperazone can occur, which can limit its effectiveness. Resistance can occur through several mechanisms, including the production of beta-lactamase enzymes that can inactivate cefbuperazone, and modifications to the PBPs that cefbuperazone binds to.

See Also

• Cephalosporin
• Beta-lactam antibiotics
• Penicillin-binding proteins
• Beta-lactamase

This article is a stub. You can help WikiMD by registering to expand it. Editing is available only to registered and verified users. WikiMD is a comprehensive, free health & wellness encyclopedia.