Cefbuperazone
Cefbuperazone is a cephalosporin antibiotic, a class of beta-lactam antibiotics that are used in the treatment of various bacterial infections. It is a broad-spectrum antibiotic, meaning it is effective against a wide range of bacteria.
Chemistry[edit | edit source]
Cefbuperazone belongs to the third generation of cephalosporins. Like all cephalosporins, it contains a beta-lactam ring, a chemical structure that is crucial for its antibacterial activity. The beta-lactam ring interferes with the synthesis of the bacterial cell wall, leading to the death of the bacteria.
Pharmacology[edit | edit source]
Cefbuperazone works by inhibiting the synthesis of the bacterial cell wall. It binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. This binding leads to the inhibition of the third and last stage of bacterial cell wall synthesis, which is ultimately lethal to the bacteria.
Clinical Use[edit | edit source]
Cefbuperazone is used to treat a variety of bacterial infections, including those caused by Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae. It is also used in the treatment of infections caused by Pseudomonas aeruginosa, a bacterium that is often resistant to other antibiotics.
Side Effects[edit | edit source]
Like all antibiotics, cefbuperazone can cause side effects. The most common side effects include nausea, vomiting, and diarrhea. In rare cases, cefbuperazone can cause serious side effects such as allergic reactions, kidney damage, and Clostridium difficile-associated diarrhea.
Resistance[edit | edit source]
Bacterial resistance to cefbuperazone can occur, which can limit its effectiveness. Resistance can occur through several mechanisms, including the production of beta-lactamase enzymes that can inactivate cefbuperazone, and modifications to the PBPs that cefbuperazone binds to.
See Also[edit | edit source]
| This article is a stub. You can help WikiMD by registering to expand it. |
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
