Cefclidin

Cefclidin is a cephalosporin antibiotic used in the treatment of various bacterial infections. It belongs to the third generation of cephalosporins and is known for its broad-spectrum activity against a wide range of Gram-positive and Gram-negative bacteria.

Mechanism of Action

Cefclidin works by inhibiting the synthesis of the bacterial cell wall. It binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, leading to the inhibition of the third and last stage of bacterial cell wall synthesis. This eventually results in cell lysis.

Pharmacokinetics

After oral administration, Cefclidin is absorbed from the gastrointestinal tract and widely distributed throughout the body. It is primarily excreted unchanged in the urine.

Clinical Uses

Cefclidin is used to treat a variety of infections caused by susceptible bacteria, including respiratory tract infections, skin infections, and urinary tract infections. It is also used in the treatment of septicemia, meningitis, and other serious infections.

Side Effects

Common side effects of Cefclidin include nausea, vomiting, diarrhea, and abdominal pain. In rare cases, it can cause serious side effects such as allergic reactions, kidney damage, and blood disorders.

Contraindications

Cefclidin is contraindicated in patients with a known allergy to cephalosporin antibiotics. It should be used with caution in patients with a history of kidney disease or gastrointestinal disease.

Interactions

Cefclidin may interact with other medications, including probenecid, warfarin, and live bacterial vaccines. It is important to inform the healthcare provider of all medications being taken before starting treatment with Cefclidin.

See Also

• Cephalosporin
• Antibiotics
• Bacterial Infections