Cefmenoxime hydrochloride

Cefmenoxime hydrochloride is a cephalosporin antibiotic used in the treatment of various bacterial infections. It is a third-generation cephalosporin that is primarily used against gram-negative bacteria, but also has some activity against gram-positive bacteria.

Mechanism of Action

Cefmenoxime hydrochloride works by inhibiting the synthesis of the bacterial cell wall. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. This leads to cell lysis and death.

Medical Uses

Cefmenoxime hydrochloride is used to treat a variety of bacterial infections, including pneumonia, meningitis, sepsis, and infections of the skin, bone, joint, urinary tract, and gastrointestinal tract. It is also used in the treatment of gonorrhea and pelvic inflammatory disease.

Side Effects

Common side effects of cefmenoxime hydrochloride include nausea, vomiting, diarrhea, and rash. In rare cases, it can cause serious side effects such as anaphylaxis, Clostridium difficile-associated diarrhea, and neutropenia.

Drug Interactions

Cefmenoxime hydrochloride can interact with other medications, including probenecid, which can increase the levels of cefmenoxime in the body. It can also interact with aminoglycosides, increasing the risk of kidney damage.

Pharmacokinetics

After intravenous administration, cefmenoxime hydrochloride is widely distributed in the body. It is primarily excreted unchanged in the urine.

See Also

• Cephalosporin
• Antibiotics
• Bacterial Infections

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