Cefoperazone/sulbactam

Cefoperazone/sulbactam is a combination antibiotic used in the treatment of various bacterial infections. It is a combination of two active ingredients: cefoperazone, a third-generation cephalosporin, and sulbactam, a beta-lactamase inhibitor. This combination is particularly effective because sulbactam enhances the effectiveness of cefoperazone by inhibiting the enzymes that would otherwise degrade it.

Mechanism of Action[edit | edit source]

Cefoperazone works by inhibiting the synthesis of the bacterial cell wall, leading to cell death. Sulbactam, on the other hand, inhibits beta-lactamase, an enzyme produced by certain bacteria that can degrade and inactivate cefoperazone. By inhibiting this enzyme, sulbactam allows cefoperazone to remain active and exert its antibacterial effects.

Uses[edit | edit source]

Cefoperazone/sulbactam is used to treat a variety of bacterial infections, including those caused by Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus. It is also used in the treatment of intra-abdominal infections, skin and soft tissue infections, and respiratory tract infections.

Side Effects[edit | edit source]

Common side effects of cefoperazone/sulbactam include nausea, vomiting, diarrhea, and rash. In rare cases, it can cause more serious side effects such as anaphylaxis, a severe allergic reaction.

Precautions[edit | edit source]

Patients with a history of allergy to cephalosporins or other beta-lactam antibiotics should not use cefoperazone/sulbactam. It should also be used with caution in patients with kidney disease or liver disease, as these conditions can affect the body's ability to metabolize and eliminate the drug.

Interactions[edit | edit source]

Cefoperazone/sulbactam can interact with other medications, including probenecid, which can increase the levels of cefoperazone in the body, and alcohol, which can lead to a disulfiram-like reaction when combined with cefoperazone.