Ceftezole

Ceftezole is a cephalosporin antibiotic used in the treatment of bacterial infections. It belongs to the second generation of cephalosporins and is primarily used against infections caused by Gram-negative bacteria.

Mechanism of Action[edit | edit source]

Ceftezole works by inhibiting the synthesis of the bacterial cell wall, leading to cell death. It binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.

Pharmacokinetics[edit | edit source]

After administration, Ceftezole is well absorbed and widely distributed in the body. It is primarily excreted unchanged in the urine. The half-life of Ceftezole is approximately 2 hours.

Clinical Use[edit | edit source]

Ceftezole is used to treat a variety of infections caused by susceptible bacteria. These include urinary tract infections, respiratory tract infections, skin and soft tissue infections, and bone and joint infections. It is also used for surgical prophylaxis in patients undergoing surgical procedures where a risk of infection is present.

Side Effects[edit | edit source]

Common side effects of Ceftezole include nausea, vomiting, diarrhea, and allergic reactions. Serious side effects may include Clostridium difficile associated diarrhea, Stevens-Johnson syndrome, and anaphylaxis.

Resistance[edit | edit source]

Resistance to Ceftezole can occur through several mechanisms, including the production of beta-lactamase enzymes, alteration of PBPs, and changes in outer membrane permeability.

See Also[edit | edit source]

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