Celecoxib/tramadol
Celecoxib/Tramadol
Celecoxib/tramadol is a combination of two drugs, Celecoxib and Tramadol, used for the management of acute pain and chronic pain conditions. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. Tramadol is an opioid analgesic that works on the central nervous system to relieve pain.
Pharmacology[edit | edit source]
Celecoxib belongs to the class of drugs known as COX-2 inhibitors. It works by blocking the enzyme cyclooxygenase-2 (COX-2), which plays a key role in the production of prostaglandins. Prostaglandins are chemicals that promote inflammation, pain, and fever. By blocking the production of prostaglandins, celecoxib reduces these symptoms.
Tramadol is a centrally acting opioid analgesic. It binds to the mu-opioid receptors in the brain, blocking the transmission of pain signals. Tramadol also increases the levels of serotonin and norepinephrine, neurotransmitters that can modulate the perception of pain.
Indications[edit | edit source]
Celecoxib/tramadol is indicated for the relief of moderate to severe pain in adults. It is commonly used in conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute pain.
Side Effects[edit | edit source]
Common side effects of celecoxib/tramadol include nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, or sweating. Serious side effects may include slow/shallow breathing, severe stomach/abdominal pain, signs of kidney problems, or signs of liver disease.
Interactions[edit | edit source]
Celecoxib/tramadol may interact with other medications, including other NSAIDs, antidepressants, antipsychotics, and anticoagulants. It is important to inform your healthcare provider of all medications you are currently taking.
Precautions[edit | edit source]
Before taking celecoxib/tramadol, inform your healthcare provider if you have any allergies, or if you have a history of heart disease, liver disease, kidney disease, stomach/intestinal problems, or mental/mood disorders.
See Also[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
