From WikiMD's Wellness Encyclopedia


Celecoxib/tramadol is a combination of two drugs, Celecoxib and Tramadol, used for the management of acute pain and chronic pain conditions. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. Tramadol is an opioid analgesic that works on the central nervous system to relieve pain.

Pharmacology[edit | edit source]

Celecoxib belongs to the class of drugs known as COX-2 inhibitors. It works by blocking the enzyme cyclooxygenase-2 (COX-2), which plays a key role in the production of prostaglandins. Prostaglandins are chemicals that promote inflammation, pain, and fever. By blocking the production of prostaglandins, celecoxib reduces these symptoms.

Tramadol is a centrally acting opioid analgesic. It binds to the mu-opioid receptors in the brain, blocking the transmission of pain signals. Tramadol also increases the levels of serotonin and norepinephrine, neurotransmitters that can modulate the perception of pain.

Indications[edit | edit source]

Celecoxib/tramadol is indicated for the relief of moderate to severe pain in adults. It is commonly used in conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute pain.

Side Effects[edit | edit source]

Common side effects of celecoxib/tramadol include nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, or sweating. Serious side effects may include slow/shallow breathing, severe stomach/abdominal pain, signs of kidney problems, or signs of liver disease.

Interactions[edit | edit source]

Celecoxib/tramadol may interact with other medications, including other NSAIDs, antidepressants, antipsychotics, and anticoagulants. It is important to inform your healthcare provider of all medications you are currently taking.

Precautions[edit | edit source]

Before taking celecoxib/tramadol, inform your healthcare provider if you have any allergies, or if you have a history of heart disease, liver disease, kidney disease, stomach/intestinal problems, or mental/mood disorders.

See Also[edit | edit source]


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Contributors: Prab R. Tumpati, MD