From WikiMD's Wellness Encyclopedia

Centromedian nucleus is a part of the thalamus, which is a large mass of gray matter located in the dorsal part of the diencephalon. The centromedian nucleus is one of the components of the intralaminar nucleus of the thalamus. It plays a significant role in the modulation of pain and the integration of diverse information to the cerebral cortex.

Anatomy[edit | edit source]

The centromedian nucleus is located in the posterior part of the thalamus. It is one of the largest nuclei of the thalamus and is located medially in the intralaminar nucleus. The centromedian nucleus is closely related to the reticular nucleus of the thalamus.

Function[edit | edit source]

The centromedian nucleus is involved in several functions, including the modulation of pain, arousal, and attention. It receives inputs from various areas of the brain, including the basal ganglia, brainstem, and cerebral cortex. The centromedian nucleus sends projections to the cerebral cortex and basal ganglia, playing a crucial role in the integration of diverse information.

Clinical significance[edit | edit source]

Alterations in the function of the centromedian nucleus have been associated with several neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and chronic pain. Deep brain stimulation of the centromedian nucleus has been used as a treatment for these disorders.

See also[edit | edit source]

References[edit | edit source]

Centromedian Resources

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Contributors: Prab R. Tumpati, MD