Cephradine

From WikiMD's Wellness Encyclopedia

Cephradine is a first-generation cephalosporin antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. It is effective against a wide range of bacterial infections, including those affecting the respiratory tract, urinary tract, skin, and soft tissues. Cephradine works by inhibiting the synthesis of the bacterial cell wall, leading to cell death.

Medical Uses[edit | edit source]

Cephradine is indicated for the treatment of various bacterial infections, including:

Pharmacology[edit | edit source]

Cephradine is a bactericidal agent that acts by inhibiting the synthesis of the bacterial cell wall. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, disrupting the final transpeptidation step of peptidoglycan synthesis. This leads to weakening of the cell wall and ultimately causes cell lysis and death.

Administration[edit | edit source]

Cephradine can be administered orally or as a parenteral formulation. The dosage and duration of therapy depend on the type and severity of the infection as well as the patient's age and renal function.

Side Effects[edit | edit source]

Common side effects of cephradine include:

  • Gastrointestinal disturbances such as nausea, vomiting, and diarrhea
  • Allergic reactions, which may manifest as rash, pruritus, or more severe reactions in hypersensitive individuals
  • Transient increases in liver enzymes

Precautions[edit | edit source]

Patients with a history of hypersensitivity to cephalosporins or penicillins should use cephradine with caution due to the potential for cross-reactivity. It should also be used with caution in patients with renal impairment, with dose adjustments as necessary.

Drug Interactions[edit | edit source]

Cephradine may interact with other medications, including:

  • Probenecid, which can increase cephradine serum levels by decreasing renal excretion
  • Anticoagulants, as cephradine may potentiate the effects of anticoagulants and increase the risk of bleeding

Conclusion[edit | edit source]

Cephradine is a valuable antibiotic in the treatment of various bacterial infections. Its effectiveness against a broad spectrum of bacteria, coupled with its safety profile, makes it a useful option in the management of infections in both adults and children.


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Contributors: Prab R. Tumpati, MD